E6AP inhibits G-CSFR turnover and functions by promoting its ubiquitin-dependent proteasome degradation
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چکیده
منابع مشابه
SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation
Sirtuin6(SIRT6) has been implicated as a key factor in aging and aging-related diseases. However, the role of SIRT6 in cellular senescence has not been fully understood. Here, we show that SIRT6 repressed the expression of p27Kip1 (p27) in cellular senescence. The expression of SIRT6 was reduced during cellular senescence, whereas enforced SIRT6 expression promoted cell proliferation and antago...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2017
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2017.05.026